John L Waddington Selected Research

Neuregulin-1 (Neuregulin 1)

10/2019	D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
1/2017	Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1.
1/2017	Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the "Prism" of Schizophrenia.
1/2017	Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.
1/2017	Specialized Information Processing Deficits and Distinct Metabolomic Profiles Following TM-Domain Disruption of Nrg1.
5/2012	Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.
3/2009	Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice.
2/2009	Mutant models for genes associated with schizophrenia.
1/2009	Neuregulin-1 signaling in schizophrenia: 'Jack of all trades' or master of some?
2/2008	Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1.

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John L Waddington Research Topics

Disease

52	Schizophrenia (Dementia Praecox) 10/2022 - 09/2002
16	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 09/2002
6	Seizures (Absence Seizure) 11/2015 - 02/2004
4	Movement Disorders (Movement Disorder) 01/2021 - 03/2009
4	Parkinson Disease (Parkinson's Disease) 04/2020 - 08/2012
3	Cognitive Dysfunction 01/2022 - 10/2017
3	Parkinsonian Disorders (Parkinsonism) 12/2021 - 04/2020
3	Bipolar Disorder (Manic Depressive Psychosis) 01/2020 - 09/2010
3	Huntington Disease (Huntington's Disease) 04/2015 - 09/2011
3	Dyskinesias (Dyskinesia) 02/2014 - 03/2009
2	Hypoxia (Hypoxemia) 07/2022 - 11/2015
2	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2020 - 04/2020
2	Major Depressive Disorder (Major Depressive Disorders) 01/2018 - 07/2013
2	Pain (Aches) 01/2017 - 03/2012
1	Treatment-Resistant Schizophrenia 01/2021
1	Hyperglycemia 12/2020
1	Neurodevelopmental Disorders 04/2020
1	Neuroinflammatory Diseases 01/2018
1	Neurobehavioral Manifestations 10/2017
1	DiGeorge Syndrome (Syndrome, DiGeorge) 03/2015
1	Tics (Tic) 02/2014
1	Body Weight (Weight, Body) 02/2014
1	Ataxia (Dyssynergia) 02/2014
1	Diphtheria 01/2013
1	Hypersensitivity (Allergy) 01/2013
1	Atrophy 01/2013
1	Epilepsy (Aura) 07/2012
1	Nervous System Diseases (Neurological Disorders) 07/2012
1	Status Epilepticus (Complex Partial Status Epilepticus) 07/2012
1	AIDS-Related Complex (ARC) 05/2011
1	Autistic Disorder (Autism) 01/2011

Drug/Important Bio-Agent (IBA)

20	Antipsychotic Agents (Antipsychotics)IBA 01/2022 - 02/2003
14	Neuregulin-1 (Neuregulin 1)IBA 10/2019 - 01/2006
9	Dopamine (Intropin)FDA LinkGeneric 10/2022 - 02/2004
7	DysbindinIBA 01/2020 - 04/2003
6	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 10/2012 - 01/2007
5	Protein Isoforms (Isoforms)IBA 10/2022 - 05/2017
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2012
5	Biological ProductsIBA 07/2013 - 09/2002
3	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 10/2012
3	Dopamine Receptors (Dopamine Receptor)IBA 04/2015 - 09/2011
3	EnzymesIBA 10/2012 - 03/2012
2	Sigma-1 ReceptorIBA 01/2022 - 04/2020
2	Phencyclidine (Angel Dust)IBA 01/2022 - 10/2019
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2022 - 01/2018
2	Silver Sulfadiazine (SSD)FDA LinkGeneric 12/2021 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2013
2	Clozapine (Clozaril)FDA LinkGeneric 01/2021 - 01/2011
2	dihydromyricetinIBA 04/2020 - 01/2018
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 02/2017 - 08/2012
2	MicroRNAs (MicroRNA)IBA 01/2017 - 07/2012
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 07/2005
2	insulin receptor-related receptor (IRR)IBA 01/2014 - 01/2010
2	CannabinoidsIBA 10/2012 - 05/2011
2	ConvulsantsIBA 05/2011 - 06/2008
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 06/2008 - 02/2006
2	Type C PhospholipasesIBA 06/2008 - 02/2006
2	GTP-Binding Proteins (G-Protein)IBA 01/2007 - 02/2004
1	metal transporting protein 1 (ferroportin)IBA 07/2022
1	IronIBA 07/2022
1	3- methylphenyl- 2,3,4,5- tetrahydro- 1H- benzo(d)azepin- 7- olIBA 01/2022
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 01/2022
1	2- (4- morpholino)ethyl- 1- phenylcyclohexane- 1- carboxylateIBA 01/2022
1	Therapeutic UsesIBA 01/2022
1	Unithiol (DMPS)IBA 01/2021
1	QuinpiroleIBA 12/2020
1	Adrenergic Receptors (Adrenergic Receptor)IBA 12/2020
1	ICI 118551IBA 12/2020
1	Sulpiride (neogama)IBA 12/2020
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 12/2020
1	ElementsIBA 04/2020
1	Antidepressive Agents (Antidepressants)IBA 01/2018
1	CytokinesIBA 01/2017
1	NeuregulinsIBA 01/2017
1	mouse MIRN29 microRNAIBA 01/2017
1	Caspase 3 (Caspase-3)IBA 11/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2015
1	Oxygen (Dioxygen)IBA 11/2015
1	Kainic Acid (Kainate)IBA 11/2015
1	Phenobarbital (Luminal)FDA Link 11/2015
1	Phosphotransferases (Kinase)IBA 06/2014
1	Haloperidol (Haldol)FDA LinkGeneric 02/2014
1	Morphine (MS Contin)FDA LinkGeneric 01/2013
1	(3R)- ((2,3- dihydro- 5- methyl- 3- ((4- morpholinyl)methyl)pyrrolo- (1,2,3- de)- 1,4- benzoxazin- 6- yl)(1- naphthalenyl))methanone (WIN 55,212)IBA 10/2012
1	AntagomirsIBA 07/2012
1	Neurotransmitter Agents (Neurotransmitter)IBA 06/2012
1	Pharmaceutical PreparationsIBA 05/2012
1	TransferasesIBA 05/2012
1	catechol (pyrocatechol)IBA 05/2012
1	CatecholaminesIBA 03/2012
1	Dopamine D1 Receptors (Dopamine D1 Receptor)IBA 05/2011
1	SCH 23390IBA 05/2011
1	SK&F 81297IBA 05/2011
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 05/2011

Therapy/Procedure

5	Lasers (Laser) 01/2020 - 09/2005
3	Therapeutics 04/2020 - 11/2012
1	Vagotomy 12/2020
1	Aftercare (After-Treatment) 02/2017
1	Induced Hypothermia 01/2017
1	Secondary Prevention 12/2010